HOX11, a Homeobox-Containing T-Cell Oncogene on Human Chromosome 10q24

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 88; no. 20; pp. 8900 - 8904
• Main Authors: Kennedy, M. A., Gonzalez-Sarmiento, R., Kees, U. R., Lampert, F., Dear, N., Boehm, T., Rabbitts, T. H.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 15.10.1991; National Acad Sciences
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Cell Line; Cell lines; chromosome 10; Chromosome Banding; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 7; Complementary DNA; DNA; DNA, Neoplasm - genetics; DNA, Neoplasm - isolation & purification; DNA-Binding Proteins - genetics; Exons; Genes; Genes, Homeobox; Genomics; Hematologic and hematopoietic diseases; Homeobox genes; Homeodomain Proteins; HOX11; Humans; Introns; Leukemia-Lymphoma, Adult T-Cell - genetics; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mice; Molecular Sequence Data; Oncogene Proteins - genetics; Oncogenes; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell, alpha-beta - genetics; Receptors, Antigen, T-Cell, gamma-delta - genetics; Restriction Mapping; Sequence Homology, Nucleic Acid; T lymphocytes; T-Lymphocytes - physiology; Translocation, Genetic; tumorigenesis; Tumors; Chromosomal aberration; Human; Nucleotide sequence; Cleavage site; Acute; Leukemia; Malignant hemopathy; Gene expression; Carcinogenesis; C10-Chromosome; T-Lymphocyte; Abnormal chromosome; Onc gene; Homeobox sequence; Chromosome translocation
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.88.20.8900

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.