High prevalence of Clonorchis sinensis infections and coinfection with hepatitis virus in riverside villages in northeast China

• Published in: Scientific reports Vol. 10; no. 1; p. 11749
• Main Authors: Gao, Yanhang, Li, Yanqing, Liu, Xiaowen, Zhang, Tong, Yu, Ge, Wang, Yang, Shi, Ying, Chi, Xiumei, Wang, Xiaomei, Gao, Xiuzhu, Wu, Ruihong, Zhang, Yingyu, Hang, Lei, Sun, Shijuan, Guan, Yazhe, Xu, Ying, Meng, Jing, Liu, Xu, Jiang, Chang, Ma, Heming, Luo, Liting, Yan, Qi, Yin, Xin, Peng, Fei, Zhi, Yixiao, Qu, Weige, Zhang, Xia, Ren, Tianqi, Liu, Lili, Zhao, Jinming, Zhang, Feiyu, Yakepu, Adila, Pan, Yu, Xu, Hongqin, Niu, Junqi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.07.2020; Nature Publishing Group
• Subjects: 692/4020; 692/700; Adult; Aged; Animals; Antiparasitic agents; China - epidemiology; Clonorchiasis - epidemiology; Clonorchiasis - parasitology; Clonorchiasis - transmission; Clonorchis sinensis; Coinfection; Female; Freshwater fish; Hepatitis; Hepatitis B; Hepatitis, Viral, Human - epidemiology; Hepatitis, Viral, Human - transmission; Hepatitis, Viral, Human - virology; Humanities and Social Sciences; Humans; Infections; Male; Middle Aged; multidisciplinary; Odds Ratio; Prevalence; Public Health Surveillance; Risk factors; Rivers; Science; Science (multidisciplinary); Villages; Young Adult; China
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-68684-x

In China, the prevalence of Clonorchis sinensis ( C. sinensis ) infections is only evaluated at the provincial level by national sampling surveys, and data from villages and counties are still lacking. In this study, we conducted a cross-sectional survey in 10 villages located along the Lalin River in northeast China. Clonorchiasis was diagnosed using a modified Kato–Katz method that detects the C. sinensis egg in stools. A total of 3,068 persons were screened and 2,911 were recruited for the study. Overall, the prevalence of C. sinensis infection was 29.3%. Among 175 participants who were cured after antiparasitic treatment, 54 (30.86%) were re-infected in this survey. After calibration of potential confounders, male gender, occupation as a farmer, smoking, and occasionally or frequently eating raw fish were independent risk factors for C. sinensis infection. The results of laboratory examinations in the C. sinensis /hepatitis B or C virus co-infection group were similar to those in the hepatitis B or C virus mono-infection groups. In conclusion, C. sinensis is highly endemic in villages along the Lalin River, and the primary route of infection is the consumption of raw freshwater fish. Co-infection with C. sinensis did't aggravate the clinical manifestations of viral hepatitis in this cross-sectional study.