Azadirachta indica A. Juss. In Vivo Toxicity-An Updated Review

The Neem tree, A. Juss., is known for its large spectrum of compounds with biological and pharmacological interest. These include, among others, activities that are anticancer, antibacterial, antiviral, and anti-inflammatory. Some neem compounds are also used as insecticides, herbicides, and/or anti...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 2; p. 252
Main Authors Braga, Teresa M, Rocha, Lídia, Chung, Tsz Yan, Oliveira, Rita F, Pinho, Cláudia, Oliveira, Ana I, Morgado, Joaquim, Cruz, Agostinho
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.01.2021
MDPI
Subjects
Animals
Antifeedants
Aquatic animals
Azadirachta - chemistry
Azadirachta indica
Biocompatibility
Embryos
Herbicides
Humans
in vivo
In vivo methods and tests
Inflammation
Insecticides
Insecticides - chemistry
Insecticides - toxicity
Literature reviews
Neem
Pesticides
Plant Extracts - chemistry
Plant Extracts - toxicity
Review
Toxicity
India
toxicity
in vivo
Azadirachta indica
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Summary:The Neem tree, A. Juss., is known for its large spectrum of compounds with biological and pharmacological interest. These include, among others, activities that are anticancer, antibacterial, antiviral, and anti-inflammatory. Some neem compounds are also used as insecticides, herbicides, and/or antifeedants. The safety of these compounds is not always taken into consideration and few in vivo toxicity studies have been performed. The current study is a literature review of the latest in vivo toxicity of . It is divided in two major sections-aquatic animals toxicity and mammalian toxicity-each related to neem's application as a pesticide or a potential new therapeutic drug, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26020252