IMMUNOHISTOCHEMICAL LOCALIZATION OF DIPEPTIDYL AMINOPEPTIDASE (DAP) IV IN THE RAT ENDOCRINE ORGANS

Immunohistochemical localization of dipeptidyl aminopeptidase (DAP) IV in the rat endocrine organs was studied using the unlabeled antibody method. Fresh frozen, chloroform-acetone treated sections of the endocrine organs (pineal, pituitary, thyroid, parathyroid, adrenal gland and pancreas) were inv...

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Published inACTA HISTOCHEMICA ET CYTOCHEMICA Vol. 14; no. 6; pp. 581 - 587
Main Authors SAHARA, NORIYUKI, FUKASAWA, KATSUHIKO, HARADA, MINORU, SUZUKI, KAZUO
Format Journal Article
LanguageEnglish
Published Sendai JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 01.01.1981
Japan Science and Technology Agency
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Summary:Immunohistochemical localization of dipeptidyl aminopeptidase (DAP) IV in the rat endocrine organs was studied using the unlabeled antibody method. Fresh frozen, chloroform-acetone treated sections of the endocrine organs (pineal, pituitary, thyroid, parathyroid, adrenal gland and pancreas) were investigated for the present study. A fairly intense immunoreaction of DAP IV was detected in the capillary endothelium of the thyroid gland and adrenal cortex. The capillary endothelium of the pineal, pituitary, parathyroid gland and pancreatic islets showed faint immunoreaction. No immunoreaction could be seen in the parenchymal cells of these endocrine organs except for the follicular epithelial cells of the thyroid gland. These results indicated that DAP IV in the endocrine organs was restricted to the capillary endothelium, and showed organ-dependent differences. Especially, it seemed that DAP IV in the capillary endothelium might be of importance in the thyroid and adrenal glands.
ISSN:0044-5991
1347-5800
DOI:10.1267/ahc.14.581