Prevalence and Clinical Correlates of Isolated Mitral, Isolated Aortic Regurgitation, and Both in Adults Aged 21 to 35 Years (from the CARDIA Study)

• Published in: The American journal of cardiology Vol. 99; no. 6; pp. 830 - 834
• Main Authors: Reid, Cheryl L., MD, Anton-Culver, Hoda, PhD, Yunis, Carla, PhD, Gardin, Julius M., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.03.2007; Elsevier; Elsevier Limited
• Subjects: Adult; Aortic Valve Insufficiency - complications; Aortic Valve Insufficiency - diagnostic imaging; Aortic Valve Insufficiency - epidemiology; Aortic Valve Insufficiency - pathology; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cohort Studies; Coronary vessels; Correlation analysis; Echocardiography, Doppler, Color; Endocardial and cardiac valvular diseases; Female; Heart; Human subjects; Humans; Incidence; Male; Medical sciences; Mitral Valve Insufficiency - complications; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - epidemiology; Mitral Valve Insufficiency - pathology; Prevalence; Severity of Illness Index; Ultrasonic imaging; United States - epidemiology; Young adults; Human; Mitral valve; Prevalence; Cardiovascular disease; Aortic regurgitation; Epidemiology; Phlebology; Cardiac valvular disease; Mitral regurgitation; Adult; Circulatory system; Cardiology; Aortic valve; Public health
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2006.10.048

Aortic regurgitation (AR) and mitral regurgitation (MR) can result in serious clinical complications and death. The physiologic and clinical correlates of AR and MR in a free-living young adult population, however, have not been well defined. The prevalence and correlates of AR and MR were investigated in Coronary Artery Risk Development in Young Adults (CARDIA), a multicenter National Heart, Lung, and Blood Institute study of 4,352 men and women aged 21 to 35 years who had 2-dimensionally directed M-mode echocardiographic and spectral and color Doppler examinations. Isolated MR by color Doppler was detected in 10.4% (90.4% with trivial or mild severity). Isolated AR by color Doppler was present in 0.8% (37.7% with mild severity). Combined AR and MR occurred in 0.5%. There was no association between body mass index and the prevalence or severity of MR or AR. Left ventricular mass was greater in subjects with isolated AR (mean ± SD 172 ± 49 g) than in those with MR (155 ± 48 g) and greater in both groups than in subjects without MR and AR (148 ± 44 g). AR was associated with increased aortic root diameter, whereas subjects with isolated MR and those with AR and MR had increased left atrial dimensions and greater left ventricular internal dimensions. In conclusion, MR and AR detected by color Doppler echocardiography are relatively uncommon in a healthy young adult population, but both are associated with evidence of increased left ventricular dimensions and mass.