Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 109 cfu heat-killed L. plantarum OLL2712 for 12 wk sho...

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Published inJournal of Nutritional Science and Vitaminology Vol. 59; no. 2; pp. 144 - 147
Main Authors SAKAI, Tohru, TAKI, Tomoyo, NAKAMOTO, Akiko, SHUTO, Emi, TSUTSUMI, Rie, TOSHIMITSU, Takayuki, MAKINO, Seiya, IKEGAMI, Shuuji
Format Journal Article
LanguageEnglish
Published Japan Center for Academic Publications Japan 2013
Subjects
adipose tissue
Adipose Tissue - metabolism
Animals
Blood Glucose - metabolism
Cholesterol - blood
Diet, High-Fat
Fatty Acids, Nonesterified - blood
inflammation
Insulin - blood
Interleukin-1beta - blood
Lactobacillus plantarum
Lipid Metabolism - physiology
Male
Mice
Mice, Inbred C57BL
obesity
Obesity - metabolism
Probiotics
RNA, Messenger - metabolism
Triglycerides - blood
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Summary:The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 109 cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.59.144