QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics

Abstract Summary QuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally verified (known) and computationally predicted (new) interactions between 5494 drugs and 2807 human proteins in DrugBank, and bet...

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Bibliographic Details
Published inBioinformatics Vol. 36; no. 12; pp. 3935 - 3937
Main Authors Li, Hongchun, Pei, Fen, Taylor, D Lansing, Bahar, Ivet
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.06.2020
Subjects
Applications Notes
Databases, Factual
Humans
Internet
Polypharmacology
Proteins - genetics
Software
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Summary:Abstract Summary QuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally verified (known) and computationally predicted (new) interactions between 5494 drugs and 2807 human proteins in DrugBank, and between 315 514 chemicals and 9457 human proteins in the STITCH database. In addition, QuartataWeb links targets to KEGG pathways and GO annotations, completing the bridge from drugs/chemicals to function via protein targets and cellular pathways. It allows users to query a series of chemicals, drug combinations or multiple targets, to enable multi-drug, multi-target, multi-pathway analyses, toward facilitating the design of polypharmacological treatments for complex diseases. Availability and implementation QuartataWeb is freely accessible at http://quartata.csb.pitt.edu. Supplementary information Supplementary data are available at Bioinformatics online.
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The authors wish it to be known that, in their opinion, Hongchun Li and Fen Pei should be regarded as Joint First Authors.
ISSN:1367-4803
1367-4811
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btaa210