IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-st...
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Published in | Scientific reports Vol. 8; no. 1; pp. 6182 - 8 |
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Main Authors | , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
18.04.2018
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole
IL13
gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of
IL13
(ATG and ATA, ordered rs1881457
C
-rs2069744
T
-rs20541
A
) significantly contributed to the risk of CAD with adjusted
p
values less than 0.05 (
p
adj
= 0.019 and
p
adj
= 0.042, respectively). In subgroup population analyses, the variant rs1881457
C
was found to significantly contribute to a nearly two fold increase in the risk of CAD in men (
p
adj
= 0.023, OR = 1.91, 95% CI: 1.09-3.33). The variant rs1881457
C
also significantly contributed to a nearly twofold risk of late-onset CAD (
p
adj
= 0.024, OR = 1.93, 95% CI: 1.09-3.42). In conclusion,
IL13
might be involved in CAD via different mechanisms under different conditions in the Chinese Han population. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-018-24592-9 |