Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior

• Published in: Journal of psychiatric research Vol. 44; no. 5; pp. 271 - 274
• Main Authors: Campos, Simone Becho, Miranda, Débora Marques, Souza, Bruno Rezende, Pereira, Patricia Araújo, Neves, Fernando Silva, Bicalho, Maria Aparecida Camargos, Melillo, Paulo Henrique Casadei, Tramontina, Juliana, Kapczinski, Flávio, Romano-Silva, Marco Aurélio, Correa, Humberto
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2010; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Bipolar affective disorder; Bipolar disorder; Bipolar Disorder - genetics; Bipolar disorders; Female; Gene Frequency; Genes; Genetic Predisposition to Disease; Genome-Wide Association Study - methods; Genotype; Humans; Male; Medical sciences; Middle Aged; Mood disorders; Polymorphism, Genetic - genetics; Prevalence; Psychiatric disorders; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Self-Injurious Behavior - genetics; Serotonin; Suicidal behaviour; Suicide; tagSNP; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Tryptophan hydroxylase; Bipolar disorder; tagSNP; Serotonin; Suicide; Mood disorder; Enzyme; Genetic determinism; Suicide attempt; Gene; Tryptophan 5-monooxygenase; Risk factor; Neurotransmitter; Genetics; Oxidoreductases; Polymorphism
• ISSN: 0022-3956; 1879-1379
• DOI: 10.1016/j.jpsychires.2009.09.007

Abstract Bipolar disorder (BD) is a severe psychiatric illness characterized by the occurrence of elevated mood alternating with depressive episodes, having a estimated lifetime prevalence of 0.4–1.6% using DSM-IV criteria. Disturbances of the central serotonergic system has been associated with the pathophysiology of affective disorders and suicidal behavior. Tryptophan hydroxylase 2 (TPH2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. Our sample consisted of 527 subjects (303 diagnosed with bipolar disorder and 224 healthy controls) which were genotyped for eight tagSNPs ( rs4448731 , rs4565946 , rs11179000 , rs7955501 , rs10506645 , rs4760820 , rs1487275 and rs10879357 ) covering the whole gene of the human TPH2. Statistical analyses were performed using UNPHASED version 3.0.12 and Haploview® . Single markers, genotype and haplotype association analysis did not show significant genetic association with bipolar disorder or suicidal behavior. Our findings do not support the association between diagnosis of BD or suicidal behavior and TPH2 polymorphisms.