Advancements to the Axolotl Model for Regeneration and Aging

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover, the development of age-related diseases is rare in this organism. In this review, we will explore how axolotls are us...

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Published inGerontology (Basel) Vol. 66; no. 3; p. 212
Main Authors Vieira, Warren A, Wells, Kaylee M, McCusker, Catherine D
Format Journal Article
LanguageEnglish
Published Switzerland 01.05.2020
Subjects
Aging - physiology
Ambystoma mexicanum - physiology
Animals
Humans
Regeneration - physiology
Regeneration
Scar formation
Aging
Axolotl
Nerve signaling
Cancer
Immune system
Technological advances
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Summary:Loss of regenerative capacity is a normal part of aging. However, some organisms, such as the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover, the development of age-related diseases is rare in this organism. In this review, we will explore how axolotls are used as a model system to study regenerative processes, the exciting new technological advancements now available for this model, and how we can apply the lessons we learn from studying regeneration in the axolotl to understand, and potentially treat, age-related decline in humans.
ISSN:1423-0003
DOI:10.1159/000504294