Xylitol concentrations in artificial saliva after application of different xylitol dental varnishes

• Published in: Journal of applied oral science Vol. 20; no. 2; pp. 146 - 150
• Main Authors: Pereira, Agnes de Fátima Faustino, Silva, Thiago Cruvinel da, Silva, Thelma Lopes da, Caldana, Magali de Lourdes, Bastos, José Roberto Magalhães, Buzalaf, Marília Afonso Rabelo
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Faculdade de Odontologia de Bauru da Universidade de São Paulo 01.04.2012; Faculdade De Odontologia De Bauru - USP; University of São Paulo
• Subjects: Analysis of Variance; Animals; Artificial saliva; Cattle; Dental caries; Dental Caries - prevention & control; Dental Enamel - drug effects; Dentistry; DENTISTRY, ORAL SURGERY & MEDICINE; Original; Random Allocation; Saliva, Artificial - analysis; Sweetening Agents - analysis; Time Factors; Xylitol; Xylitol - analysis; Xylitol; Dental caries; Artificial saliva
• ISSN: 1678-7757; 1678-7765; 1678-7765; 1678-7757
• DOI: 10.1590/S1678-77572012000200004

The present study analyzed xylitol concentrations in artificial saliva over time after application of varnishes containing 10% and 20% xylitol. Fifteen bovine enamel specimens (8x4 mm) were randomly allocated to 3 groups (n=5/group), according to the type of varnish used: 10% xylitol, 20% xylitol and no xylitol (control). After varnish application (4 mg), specimens were immersed in vials containing 500 µL of artificial saliva. Saliva samples were collected in different times (1, 8, 12, 16, 24, 48 and 72 h) and xylitol concentrations were analyzed. Data were assessed by two-way repeated-measures ANOVA (p<0.05). Colorimetric analysis was not able to detect xylitol in saliva samples of the control group. Salivary xylitol concentrations were significantly higher up to 8 h after application of the 20% xylitol varnish. Thereafter, the 10% xylitol varnish released larger amounts of that polyol in artificial saliva. Despite the results in short-term, sustained xylitol releases could be obtained when the 10% xylitol varnish was used. These varnishes seem to be viable alternatives to increase salivary xylitol levels, and therefore, should be clinically tested to confirm their effectiveness.