Pupil response as a predictor of blindsight in hemianopia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 45; pp. 18333 - 18338
• Main Authors: Sahraie, Arash, Trevethan, Ceri T., MacLeod, Mary Joan, Urquhart, James, Weiskrantz, Lawrence
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences 05.11.2013; NATIONAL ACADEMY OF SCIENCES; National Acad Sciences
• Subjects: Adult and adolescent clinical studies; Biological and medical sciences; Biological Sciences; Brain; Eye diseases; Eyes & eyesight; Frequency ranges; Hemianopia; Hemianopsia - physiopathology; Hemispheres; Humans; Lesions; Luminance; Medical sciences; Mental stimulation; Monkeys & apes; Organic mental disorders. Neuropsychology; Photic Stimulation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychophysics; Pupil; Pupil - physiology; Pupillometry; Scotland; Vision, Ocular - physiology; Visual cortex; Scotland; Human; Spatial frequency; screening; Visual field disease; spatial vision; Pupillometry; Hemianopsia; Blindsight; Psychophysics; incidence
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1318395110

Significantly above-chance detection of stimuli presented within the field defect of patients with postgeniculate lesions is termed “blindsight.” It has been proposed that those with blindsight are more likely to benefit from visual rehabilitation by repeated stimulation, leading to increased visual sensitivity within their field defect. Establishing the incidence of blindsight and developing an objective and reliable method for its detection are of great interest. Sudden onsets of a grating pattern in the absence of any change in light flux result in a transient constriction of the pupil, termed “pupil grating response.” The existence of pupil grating responses for stimuli presented within the blindfield has previously been reported in a hemianopic patient and two monkeys with removal of the primary visual cortex unilaterally. Here, we have systematically investigated the presence of a spatial channel of processing at a range of spatial frequencies using a psychophysical forced-choice technique and obtained the corresponding pupil responses in the blindfield of 19 hemianopic patients. In addition, in 13 cases we determined the pupil responses in a sighted field location that matched the blindfield eccentricities. Our findings demonstrate that blindfield pupil responses are similar to those for the sighted field, but attenuated in amplitude. Pupillometry correctly characterized the presence or absence of a significant psychophysical response and thus is worth measuring in the cortically blindfields as a predictor of intact psychophysical capacity. The incidence of blindsight where detection performance had been investigated psychophysically over a range of spatial frequencies was 70%.