Modulation of the Immune Response by a Synthetic Adjuvant and Analogs

N-Acetylmuramyl-L-alanyl-D-isoglutamine increases the humoral immune response of mice when given in aqueous media instead of the usual water-in-oil emulsions. Moreover, this compound is adjuvant active even by the oral route. In view of studying the relation between chemical structure and biological...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 73; no. 7; pp. 2472 - 2475
Main Authors Chedid, L., Audibert, F., Lefrancier, P., Choay, J., Lederer, E.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.07.1976
National Acad Sciences
Subjects
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Amides
Animals
Antibodies
Antibody Formation - drug effects
Antigens
Emulsions
Esters
Glycopeptides - administration & dosage
Glycopeptides - immunology
Hemagglutination
Humoral immunity
Immune response
Immunization
Mice
Muramic Acids - immunology
Ovalbumin - immunology
Serum Albumin, Bovine - immunology
Structure-Activity Relationship
Subcutaneous injections
Sugar Acids - immunology
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Summary:N-Acetylmuramyl-L-alanyl-D-isoglutamine increases the humoral immune response of mice when given in aqueous media instead of the usual water-in-oil emulsions. Moreover, this compound is adjuvant active even by the oral route. In view of studying the relation between chemical structure and biological activity, several synthetic analogs were tested. The immune response could be modulated according to chemical modifications, and the synthetic analog with D- in place of L-alanine was shown to inhibit the immune response.
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ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.73.7.2472