Smell Intensity Monitoring Using Metal Oxide Semiconductor Odor Sensors during Intravenous Olfaction Test

• Published in: Chemical senses Vol. 31; no. 1; pp. 43 - 47
• Main Authors: Nakashima, Toshiyuki, Kidera, Kazuki, Miyazaki, Junji, Kuratomi, Yuichiro, Inokuchi, Akira
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2006; Oxford Publishing Limited (England)
• Subjects: Adult; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Humans; Injections, Intravenous; intranasal smell intensity; intravenous olfaction test; Japan; Male; metal oxide semiconductor odor sensor; Metals - chemistry; Monitoring, Physiologic - methods; Odorants - analysis; Olfaction. Taste; Olfactory Pathways - drug effects; Olfactory Pathways - physiology; Oxides - chemistry; Perception; Portable Odor Meter; prosultiamine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Semiconductors; Sensory Thresholds - drug effects; Sensory Thresholds - physiology; Smell - drug effects; Smell - physiology; Sodium Chloride - pharmacology; Thiamine - administration & dosage; Thiamine - analogs & derivatives; Thiamine - pharmacology; Human; Intravenous administration; Methodology; intranasal smell intensity; prosultiamine; intravenous olfaction test; metal oxide semiconductor odor sensor; Portable Odor Meter; Olfaction; Perception; Measurement method; Odor; Monitoring
• ISSN: 0379-864X; 1464-3553
• DOI: 10.1093/chemse/bjj004

The intravenous olfaction test using prosultiamine (PST) solution is simple to perform and has been used clinically in Japan. We monitored intranasal intensity of smell continuously in real time under various conditions of administration using metal oxide semiconductor odor sensors and established an optimal PST injection procedure. In this study, we found that 1) although there was fluctuation in the pattern of intensity of increase in smell in the PST original solution test, the pattern of increase in intranasal smell intensity could be stabilized by prolonging the injection time to 40 s and 2) dilution of PST with physiological saline was effective in preventing angialgia during intravenous injection. It appears that PST administration is best performed by adding 10 ml of saline to 10 mg (2 ml) of PST and injecting the resulting 12-ml solution (6× dilution) and that the best respiratory cycle for testing is once in every 2 s.