An Experimental Study of the Effect of Diindolylmethane on Alveolocyte and Hepatocyte Adhesion Strength in Mice

We studied the effect of diindolylmethane in a dose of 600 mg/kg on the change in adhesion strength of alveolocytes and hepatocytes in CBA mice. Diindolylmethane was administered intragastrically to experimental animals for 10 days, controls intragastrically received an equivalent volume of saline....

Full description

Saved in:
Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 168; no. 1; pp. 45 - 47
Main Authors Kiselev, V. I., Sukhikh, G. T., Pchelintseva, O. I., Udut, V. V., Kuznetsov, I. N., Drukh, V. M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2019
Springer
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Hepatocytes
Hepatocytes - drug effects
Indoles - pharmacology
Internal Medicine
Laboratory Medicine
Mice
Pathology
Pulmonary Alveoli - cytology
Pulmonary Alveoli - drug effects
diindolylmethane
preclinical studies
adhesion strength of alveolocytes and hepatocytes
Online AccessGet full text

Cover

More Information
Summary:We studied the effect of diindolylmethane in a dose of 600 mg/kg on the change in adhesion strength of alveolocytes and hepatocytes in CBA mice. Diindolylmethane was administered intragastrically to experimental animals for 10 days, controls intragastrically received an equivalent volume of saline. At the end of the therapeutic period, mice treated with diindolylmethane showed a significant increase in the adhesion strength of alveolocytes by 16% ( p =0.003) and hepatocytes by 61% ( p =0.0001) in comparison with the control group, which indicates the antipromotor activity of diindolylmethane.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04642-6