An invertebrate histocompatibility complex

We have developed defined genetic lines of the hydroid Hydractinia symbiolongicarpus and confirmed earlier results showing that allorecognition is controlled by a single chromosomal region within these lines. In a large backcross population, we detected recombinants that display a fusibility phenoty...

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Bibliographic Details
Published inGenetics (Austin) Vol. 167; no. 1; pp. 357 - 365
Main Authors Cadavid, Luis F, Powell, Anahid E, Nicotra, Matthew L, Moreno, Maria, Buss, Leo W
Format Journal Article
LanguageEnglish
Published United States Genetics Society of America 01.05.2004
Subjects
Alleles
Animal populations
Animals
Chromosome Mapping
Chromosomes
Cnidaria - genetics
Crosses, Genetic
Female
Gene loci
Genetic Linkage
Genetic Markers
Genetics
Genotype
Genotype & phenotype
Hydractinia symbiolongicarpus
Invertebrata
Invertebrates - genetics
Major Histocompatibility Complex
Male
Models, Genetic
Pedigree
Phenotype
Polymorphism, Genetic
Recombination, Genetic
Time Factors
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Summary:We have developed defined genetic lines of the hydroid Hydractinia symbiolongicarpus and confirmed earlier results showing that allorecognition is controlled by a single chromosomal region within these lines. In a large backcross population, we detected recombinants that display a fusibility phenotype distinct from typical fusion and rejection. We show that this transitory fusion phenotype segregates in a fashion expected of a single Mendelian trait, establishing that the chromosomal interval contains at least two genes that interact to determine fusibility. Using bulked segregant analysis, we have identified amplified fragment length polymorphisms (AFLP) cosegregating with fusibility, used these markers to independently confirm linkage of the two loci, and constructed a 3.4-cM map of an invertebrate histocompatibility complex.
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ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.167.1.357