Single-trial analysis of oddball event-related potentials in simultaneous EEG-fMRI

• Published in: Human brain mapping Vol. 28; no. 7; pp. 602 - 613
• Main Authors: Bénar, Christian-G., Schön, Daniele, Grimault, Stephan, Nazarian, Bruno, Burle, Boris, Roth, Muriel, Badier, Jean-Michel, Marquis, Patrick, Liegeois-Chauvel, Catherine, Anton, Jean-Luc
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2007; Wiley-Liss; Wiley
• Subjects: Acoustic Stimulation - methods; Adult; auditory oddball; Biological and medical sciences; Brain - blood supply; Brain - physiology; Brain Mapping; Discrimination (Psychology) - physiology; Electrodiagnosis. Electric activity recording; Electroencephalography; Event-Related Potentials, P300 - physiology; evoked potentials; Female; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Life Sciences; Magnetic Resonance Imaging; Male; Medical sciences; Nervous system; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Neurons and Cognition; Oxygen - blood; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reaction Time - physiology; simultaneous EEG-fMRI; single-trial analysis; Time Factors; Nervous system diseases; simultaneous EEG-fMRI; Radiodiagnosis; Evoked potential; auditory oddball; single-trial analysis; Electrophysiology; Electroencephalography; Nuclear magnetic resonance imaging; Event evoked potential; evoked potentials
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.20289

There has recently been a growing interest in the use of simultaneous electroencephalography (EEG) and functional MRI (fMRI) for evoked activity in cognitive paradigms, thereby obtaining functional datasets with both high spatial and temporal resolution. The simultaneous recording permits obtaining event‐related potentials (ERPs) and MR images in the same environment, conditions of stimulation, and subject state; it also enables tracing the joint fluctuations of EEG and fMRI signals. The goal of this study was to investigate the possibility of tracking the trial‐to‐trial changes in event‐related EEG activity, and of using this information as a parameter in fMRI analysis. We used an auditory oddball paradigm and obtained single‐trial amplitude and latency features from the EEG acquired during fMRI scanning. The single‐trial P300 latency presented significant correlation with parameters external to the EEG (target‐to‐target interval and reaction time). Moreover, we obtained significant fMRI activations for the modulation by P300 amplitude and latency, both at the single‐subject and at the group level. Our results indicate that, in line with other studies, the EEG can bring a new dimension to the field of fMRI analysis by providing fine temporal information on the fluctuations in brain activity. Hum Brain Mapp, 2007. © 2007 Wiley‐Liss, Inc.