atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity

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Published in	Circulation research Vol. 129; no. 8; pp. e166 - e182
Main Authors	Wang, Yong, Lu, Xiaoguang, Wang, Xiaoping, Qiu, Qi, Zhu, Ping, Ma, Lin, Ma, Xiao, Herrmann, Joerg, Lin, Xueying, Wang, Wei, Xu, Xiaolei
Format	Journal Article
Language	English
Published	United States Lippincott Williams & Wilkins 01.10.2021
Subjects	Animals Antineoplastic Agents - toxicity Autophagy - drug effects Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Cardiotoxicity Doxorubicin - toxicity Myocarditis - drug therapy Myocarditis - etiology Myocarditis - metabolism Pravastatin - pharmacology Pravastatin - therapeutic use Spironolactone - pharmacology Spironolactone - therapeutic use Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism cardiotoxicity autophagy doxorubicin zebrafish anthracycline
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Abstract	[Figure: see text].
AbstractList	[Figure: see text].[Figure: see text]. [Figure: see text].
Author	Qiu, Qi Xu, Xiaolei Wang, Wei Ma, Lin Lin, Xueying Herrmann, Joerg Lu, Xiaoguang Zhu, Ping Wang, Yong Wang, Xiaoping Ma, Xiao
AuthorAffiliation	School of Traditional Chinese Medicine (Y.W., X.W., L.M., W.W.), Beijing University of Chinese Medicine, China Cardiovascular Medicine (Y.W., X. Lu, Q.Q., P.Z., X.M., J.H., X. Lin, X.X.), Mayo Clinic, Rochester, MN
AuthorAffiliation_xml	– name: School of Traditional Chinese Medicine (Y.W., X.W., L.M., W.W.), Beijing University of Chinese Medicine, China – name: Cardiovascular Medicine (Y.W., X. Lu, Q.Q., P.Z., X.M., J.H., X. Lin, X.X.), Mayo Clinic, Rochester, MN – name: 1 Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA – name: 2 Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA – name: 3 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China – name: 4 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China – name: 5 Institute of Clinical Pharmacology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
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SubjectTerms	Animals Antineoplastic Agents - toxicity Autophagy - drug effects Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Cardiotoxicity Doxorubicin - toxicity Myocarditis - drug therapy Myocarditis - etiology Myocarditis - metabolism Pravastatin - pharmacology Pravastatin - therapeutic use Spironolactone - pharmacology Spironolactone - therapeutic use Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
Title	atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
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