Lobelia trigona Roxb-based nanomedicine with enhanced biological applications: in vitro and in vivo approach

• Published in: IET nanobiotechnology Vol. 14; no. 8; pp. 739 - 748
• Main Authors: Samdavid Thanapaul, Rex Jeya Rajkumar, Manikandan, Sreeraj K, Govindaraj, Tamil Selvan, Selvakumar, Paulraj Mosae, Enoch, Israel V.M.V, Muthukumar Nadar, Meenakshi Subbaraman Adyanpuram
• Format: Journal Article
• Language: English
• Published: United States The Institution of Engineering and Technology 01.10.2020
• Subjects: A549 human cancer cell lines; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial activity; antibacterial properties; anticancer activity; antifungal properties; antiinflammatory effects; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidants - administration & dosage; Antioxidants - chemistry; Antioxidants - pharmacology; antiproliferative effects; Bacteria - drug effects; biochemistry; biological applications; biomedical materials; burn wound‐healing activity; Burns - drug therapy; Burns - pathology; cancer; cellular biophysics; comet assay; DNA Damage; dynamic light scattering; energy dispersive X‐ray analysis; enzymes; excision; formulated LTAgNPs ointment; Fourier transform infrared spectra; Fourier transform infrared spectroscopy; free radical scavenging; Fungi - drug effects; genotoxicity effects; HeLa human cancer cell lines; in vitro approach; In Vitro Techniques; in vivo approach; lactate dehydrogenase release assay; light scattering; Lobelia - chemistry; Lobelia trigona Roxb‐based nanomedicine; Lobelia trigona Roxb‐mediated silver nanoparticles; Male; MCF‐7 human cancer cell lines; MDA‐MB‐231 human cancer cell lines; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - chemistry; microorganisms; molecular biophysics; nanofabrication; Nanomedicine; nanoparticles; Neoplasms - drug therapy; Neoplasms - pathology; nitric oxide inhibitory assay; optical properties; pathogens; Plant Extracts - pharmacology; power assay; Rats; Rats, Wistar; Research Article; scanning electron microscopy; scavenging effects; silver; Silver - chemistry; strains; structural properties; toxicology; Tumor Cells, Cultured; ultraviolet spectra; ultraviolet‐visible spectroscopy; visible spectra; Wound Healing - drug effects; wounds; antibacterial activity; cellular biophysics; burn wound-healing activity; genotoxicity effects; visible spectra; nanoparticles; Lobelia trigona Roxb-mediated silver nanoparticles; HeLa human cancer cell lines; scanning electron microscopy; excision; dynamic light scattering; wounds; power assay; MCF-7 human cancer cell lines; structural properties; optical properties; formulated LTAgNPs ointment; biomedical materials; silver; Fourier transform infrared spectroscopy; anticancer activity; MDA-MB-231 human cancer cell lines; antifungal properties; Fourier transform infrared spectra; Lobelia trigona Roxb-based nanomedicine; Ag; nanofabrication; scavenging effects; enzymes; antiproliferative effects; light scattering; strains; ultraviolet-visible spectroscopy; free radical scavenging; pathogens; nitric oxide inhibitory assay; antiinflammatory effects; toxicology; A549 human cancer cell lines; in vitro approach; nanomedicine; antibacterial properties; biological applications; energy dispersive X-ray analysis; in vivo approach; ultraviolet spectra; comet assay; microorganisms; biochemistry; lactate dehydrogenase release assay; cancer; molecular biophysics

This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet–visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dyna...