Lobelia trigona Roxb-based nanomedicine with enhanced biological applications: in vitro and in vivo approach
This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet–visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dyna...
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| Published in | IET nanobiotechnology Vol. 14; no. 8; pp. 739 - 748 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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United States
The Institution of Engineering and Technology
01.10.2020
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| Online Access | Get full text |
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| Abstract | This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet–visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and anti-fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested. LTAgNPs had potential scavenging effects on the DPPH, •OH, O2•− free radical scavenging assays and reducing power assay. LTAgNps possess strong anti-cancer activity against five human cancer cell lines (A549, MCF-7, MDA-MB-231, HeLa and KB) in a dose-dependent manner. The antiproliferative, anti-inflammatory and genotoxicity effects of LTAgNPs were further confirmed by the lactate dehydrogenase release assay, nitric oxide inhibitory assay and comet assay. Furthermore, the incision, excision and burn wound-healing activity of formulated LTAgNPs ointment was assessed in rats. All the wounds had significant healing in groups treated with LTAgNPs ointment compared to the groups treated with the commonly prescribed ointment (SilverexTM). This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications. |
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| AbstractList | This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and anti-fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested. LTAgNPs had potential scavenging effects on the DPPH, •OH, O2•- free radical scavenging assays and reducing power assay. LTAgNps possess strong anti-cancer activity against five human cancer cell lines (A549, MCF-7, MDA-MB-231, HeLa and KB) in a dose-dependent manner. The antiproliferative, anti-inflammatory and genotoxicity effects of LTAgNPs were further confirmed by the lactate dehydrogenase release assay, nitric oxide inhibitory assay and comet assay. Furthermore, the incision, excision and burn wound-healing activity of formulated LTAgNPs ointment was assessed in rats. All the wounds had significant healing in groups treated with LTAgNPs ointment compared to the groups treated with the commonly prescribed ointment (SilverexTM). This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications.This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and anti-fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested. LTAgNPs had potential scavenging effects on the DPPH, •OH, O2•- free radical scavenging assays and reducing power assay. LTAgNps possess strong anti-cancer activity against five human cancer cell lines (A549, MCF-7, MDA-MB-231, HeLa and KB) in a dose-dependent manner. The antiproliferative, anti-inflammatory and genotoxicity effects of LTAgNPs were further confirmed by the lactate dehydrogenase release assay, nitric oxide inhibitory assay and comet assay. Furthermore, the incision, excision and burn wound-healing activity of formulated LTAgNPs ointment was assessed in rats. All the wounds had significant healing in groups treated with LTAgNPs ointment compared to the groups treated with the commonly prescribed ointment (SilverexTM). This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications. This is the first study to report the green synthesis of Lobelia trigona Roxb‐ mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet–visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X‐ray. LTAgNps were evaluated for their anti‐bacterial and anti‐fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested. LTAgNPs had potential scavenging effects on the DPPH, • OH, O2 •− free radical scavenging assays and reducing power assay. LTAgNps possess strong anti‐cancer activity against five human cancer cell lines (A549, MCF‐7, MDA‐MB‐231, HeLa and KB) in a dose‐dependent manner. The antiproliferative, anti‐inflammatory and genotoxicity effects of LTAgNPs were further confirmed by the lactate dehydrogenase release assay, nitric oxide inhibitory assay and comet assay. Furthermore, the incision, excision and burn wound‐healing activity of formulated LTAgNPs ointment was assessed in rats. All the wounds had significant healing in groups treated with LTAgNPs ointment compared to the groups treated with the commonly prescribed ointment (SilverexTM). This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications. This is the first study to report the green synthesis of mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and anti-fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested. LTAgNPs had potential scavenging effects on the DPPH, OH, O free radical scavenging assays and reducing power assay. LTAgNps possess strong anti-cancer activity against five human cancer cell lines (A549, MCF-7, MDA-MB-231, HeLa and KB) in a dose-dependent manner. The antiproliferative, anti-inflammatory and genotoxicity effects of LTAgNPs were further confirmed by the lactate dehydrogenase release assay, nitric oxide inhibitory assay and comet assay. Furthermore, the incision, excision and burn wound-healing activity of formulated LTAgNPs ointment was assessed in rats. All the wounds had significant healing in groups treated with LTAgNPs ointment compared to the groups treated with the commonly prescribed ointment (Silverex ). This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications. This is the first study to report the green synthesis of Lobelia trigona Roxb‐ mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet–visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X‐ray. LTAgNps were evaluated for their anti‐bacterial and anti‐fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested. LTAgNPs had potential scavenging effects on the DPPH, • OH, O 2 •− free radical scavenging assays and reducing power assay. LTAgNps possess strong anti‐cancer activity against five human cancer cell lines (A549, MCF‐7, MDA‐MB‐231, HeLa and KB) in a dose‐dependent manner. The antiproliferative, anti‐inflammatory and genotoxicity effects of LTAgNPs were further confirmed by the lactate dehydrogenase release assay, nitric oxide inhibitory assay and comet assay. Furthermore, the incision, excision and burn wound‐healing activity of formulated LTAgNPs ointment was assessed in rats. All the wounds had significant healing in groups treated with LTAgNPs ointment compared to the groups treated with the commonly prescribed ointment (Silverex TM ). This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications. |
| Author | Selvakumar, Paulraj Mosae Muthukumar Nadar, Meenakshi Subbaraman Adyanpuram Samdavid Thanapaul, Rex Jeya Rajkumar Govindaraj, Tamil Selvan Manikandan, Sreeraj K Enoch, Israel V.M.V |
| AuthorAffiliation | 1 Department of Surgery Boston University School of Medicine Boston 02118 Massachusetts USA 5 Panaiyaanmai – Centre for self reliance and sustainable development Munnetram Green Industry Kadayam, Tenkasi Tamil Nadu India 7 Department of Nanoscience Karunya Institute of Technology & Sciences (Deemed to be University) Coimbatore 641114 Tamil Nadu India 3 Department of Chemistry Kongunadu College of Arts and Sciences Coimbatore Tamil Nadu India 4 Science and Math Program Asian University for Women Chittagong 4000 Bangladesh 6 Department of Chemistry Karunya Institute of Technology & Sciences (Deemed to be University) Coimbatore 641114 Tamil Nadu India 2 Department of Biotechnology Karunya Institute of Technology and Sciences (Deemed to be University) Coimbatore 641114 Tamil Nadu India |
| AuthorAffiliation_xml | – name: 1 Department of Surgery Boston University School of Medicine Boston 02118 Massachusetts USA – name: 2 Department of Biotechnology Karunya Institute of Technology and Sciences (Deemed to be University) Coimbatore 641114 Tamil Nadu India – name: 7 Department of Nanoscience Karunya Institute of Technology & Sciences (Deemed to be University) Coimbatore 641114 Tamil Nadu India – name: 4 Science and Math Program Asian University for Women Chittagong 4000 Bangladesh – name: 6 Department of Chemistry Karunya Institute of Technology & Sciences (Deemed to be University) Coimbatore 641114 Tamil Nadu India – name: 3 Department of Chemistry Kongunadu College of Arts and Sciences Coimbatore Tamil Nadu India – name: 5 Panaiyaanmai – Centre for self reliance and sustainable development Munnetram Green Industry Kadayam, Tenkasi Tamil Nadu India |
| Author_xml | – sequence: 1 givenname: Rex Jeya Rajkumar surname: Samdavid Thanapaul fullname: Samdavid Thanapaul, Rex Jeya Rajkumar organization: 2Department of Biotechnology, Karunya Institute of Technology and Sciences (Deemed to be University), Coimbatore-641114, Tamil Nadu, India – sequence: 2 givenname: Sreeraj K surname: Manikandan fullname: Manikandan, Sreeraj K organization: 2Department of Biotechnology, Karunya Institute of Technology and Sciences (Deemed to be University), Coimbatore-641114, Tamil Nadu, India – sequence: 3 givenname: Tamil Selvan surname: Govindaraj fullname: Govindaraj, Tamil Selvan organization: 3Department of Chemistry, Kongunadu College of Arts and Sciences, Coimbatore, Tamil Nadu, India – sequence: 4 givenname: Paulraj Mosae surname: Selvakumar fullname: Selvakumar, Paulraj Mosae organization: 5Panaiyaanmai – Centre for self reliance and sustainable development, Munnetram Green Industry, Kadayam, Tenkasi, Tamil Nadu, India – sequence: 5 givenname: Israel V.M.V surname: Enoch fullname: Enoch, Israel V.M.V organization: 7Department of Nanoscience, Karunya Institute of Technology & Sciences (Deemed to be University), Coimbatore 641114, Tamil Nadu, India – sequence: 6 givenname: Meenakshi Subbaraman Adyanpuram orcidid: 0000-0003-1584-7661 surname: Muthukumar Nadar fullname: Muthukumar Nadar, Meenakshi Subbaraman Adyanpuram email: muthukumar@karunya.edu organization: 2Department of Biotechnology, Karunya Institute of Technology and Sciences (Deemed to be University), Coimbatore-641114, Tamil Nadu, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33108332$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1515_jcim_2024_0181 crossref_primary_10_2174_0126659786278190240214062949 crossref_primary_10_1016_j_toxicon_2024_107753 crossref_primary_10_1088_2043_6262_ad2c7a crossref_primary_10_1007_s42250_023_00863_5 crossref_primary_10_1016_j_cdc_2022_100874 |
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| Keywords | antibacterial activity cellular biophysics burn wound-healing activity genotoxicity effects visible spectra nanoparticles Lobelia trigona Roxb-mediated silver nanoparticles HeLa human cancer cell lines scanning electron microscopy excision dynamic light scattering wounds power assay MCF-7 human cancer cell lines structural properties optical properties formulated LTAgNPs ointment biomedical materials silver Fourier transform infrared spectroscopy anticancer activity MDA-MB-231 human cancer cell lines antifungal properties Fourier transform infrared spectra Lobelia trigona Roxb-based nanomedicine Ag nanofabrication scavenging effects enzymes antiproliferative effects light scattering strains ultraviolet-visible spectroscopy free radical scavenging pathogens nitric oxide inhibitory assay antiinflammatory effects toxicology A549 human cancer cell lines in vitro approach nanomedicine antibacterial properties biological applications energy dispersive X-ray analysis in vivo approach ultraviolet spectra comet assay microorganisms biochemistry lactate dehydrogenase release assay cancer molecular biophysics |
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| Publisher | The Institution of Engineering and Technology |
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| Snippet | This is the first study to report the green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties of... This is the first study to report the green synthesis of Lobelia trigona Roxb‐ mediated silver nanoparticles (LTAgNPs). The optical and structural properties... This is the first study to report the green synthesis of mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised... This is the first study to report the green synthesis of Lobelia trigona Roxb‐ mediated silver nanoparticles (LTAgNPs). The optical and structural properties... |
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| SubjectTerms | A549 human cancer cell lines Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial activity antibacterial properties anticancer activity antifungal properties antiinflammatory effects Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - pharmacology antiproliferative effects Bacteria - drug effects biochemistry biological applications biomedical materials burn wound‐healing activity Burns - drug therapy Burns - pathology cancer cellular biophysics comet assay DNA Damage dynamic light scattering energy dispersive X‐ray analysis enzymes excision formulated LTAgNPs ointment Fourier transform infrared spectra Fourier transform infrared spectroscopy free radical scavenging Fungi - drug effects genotoxicity effects HeLa human cancer cell lines in vitro approach In Vitro Techniques in vivo approach lactate dehydrogenase release assay light scattering Lobelia - chemistry Lobelia trigona Roxb‐based nanomedicine Lobelia trigona Roxb‐mediated silver nanoparticles Male MCF‐7 human cancer cell lines MDA‐MB‐231 human cancer cell lines Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry microorganisms molecular biophysics nanofabrication Nanomedicine nanoparticles Neoplasms - drug therapy Neoplasms - pathology nitric oxide inhibitory assay optical properties pathogens Plant Extracts - pharmacology power assay Rats Rats, Wistar Research Article scanning electron microscopy scavenging effects silver Silver - chemistry strains structural properties toxicology Tumor Cells, Cultured ultraviolet spectra ultraviolet‐visible spectroscopy visible spectra Wound Healing - drug effects wounds |
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| Title | Lobelia trigona Roxb-based nanomedicine with enhanced biological applications: in vitro and in vivo approach |
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