Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes

• Published in: Journal of ayurveda and integrative medicine Vol. 14; no. 2; p. 100693
• Main Authors: Sukhonthasilakun, Sumrit, Mahakunakorn, Pramote, Naladta, Alisa, Nuankaew, Katesaraporn, Nualkaew, Somsak, Yenjai, Chavi, Nualkaew, Natsajee
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.03.2023; Elsevier
• Subjects: Anti-inflammation; Derris scandens; Human keratinocytes; Narrowband-ultraviolet B; Original; Phototherapy; UV protection; UV protection; Derris scandens; Human keratinocytes; Anti-inflammation; Narrowband-ultraviolet B; Phototherapy
• ISSN: 0975-9476; 0976-2809
• DOI: 10.1016/j.jaim.2023.100693

Narrowband-ultraviolet B (NB-UVB) has been used to treat skin diseases such as psoriasis. Chronic use of NB-UVB might cause skin inflammation and lead to skin cancer. In Thailand, Derris Scandens (Roxb.) Benth. is used as an alternative medicine to nonsteroidal anti-inflammatory drugs (NSAIDs) for low back pain and osteoarthritis. Therefore, this study aimed to evaluate the potential anti-inflammatory effect of Derris scandens extract (DSE) on pre- and post exposed NB-UVB human keratinocytes (HaCaT). The results indicated that DSE could not protect HaCaT from cell morphology changes or DNA fragmentation and could not recover cell proliferation ability from the NB-UVB effects. DSE treatment reduced the expression of genes related to inflammation, collagen degradation, and carcinogenesis, such as IL-1α, IL-1β, IL-6, iNOS, COX-2, MMP-1, MMP-9, and Bax. These results indicated the potential use of DSE as a topical preparation against NB-UVB-induced inflammation, anti-aging, and prevention of skin cancer from phototherapy. [Display omitted] •Derris scandens extract (DSE) possessed anti-inflammation to the narrowband-UVB exposed HaCaT.•DSE exhibited more potent activity than its major compounds.•The results suggested the potential use of DSE to reduce phototherapy side effects on skin.