The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis

• Published in: Journal of allergy and clinical immunology Vol. 148; no. 3; pp. 689 - 693
• Main Authors: Kulis, Michael D., Smeekens, Johanna M., Immormino, Robert M., Moran, Timothy P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021
• Subjects: airway; Allergens - immunology; Animals; Arachis - immunology; cutaneous; dual allergen exposure hypothesis; Food allergy; Humans; Immune Tolerance; peanut allergy; Peanut Hypersensitivity - immunology; Respiratory System - immunology; Skin - immunology; cutaneous; Food allergy; peanut allergy; airway; dual allergen exposure hypothesis; TFH; TLR
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2021.05.035

Food allergies have increased at an alarming rate over the past 2 decades, indicating that environmental factors are driving disease progression. It has been postulated that sensitization to foods, in particular, peanut, occurs through impaired skin. Peanut allergens have been quantified in household dust and may be the culprit source. Indeed, TH2 cell–skewing innate cytokines can be driven by application of food antigens on both intact and impaired skin of mice, resulting in antigen-specific IgE production and anaphylaxis following allergen exposure. However, allergy induction through the skin can be prevented by induction of oral tolerance before skin exposure. These observations led to the dual allergen exposure hypothesis, according to which oral exposure to food antigens leads to tolerance and antigen exposure on impaired skin leads to allergy. Here, we propose the airway as an alternative route of sensitization in the dual allergen exposure hypothesis that leads to food allergy. Specifically, we will provide evidence from mouse models and human cell–based studies that together implicate the airway as a plausible route of sensitization.