A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus...

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Published iniScience Vol. 24; no. 4; p. 102264
Main Authors Sinclair, Jane E., Zhu, Yanshan, Xu, Gang, Ma, Wei, Shi, Haiyan, Ma, Kun-Long, Cao, Chun-Feng, Kong, Ling-Xi, Wan, Ke-Qiang, Liao, Juan, Wang, Hai-Qiang, Arentz, Matt, Redd, Meredith A., Gallo, Linda A., Short, Kirsty R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.04.2021
Elsevier
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Omics
Virology
Omics
Virology
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Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management. [Display omitted] •Older age and male sex associated with increased SARS-CoV-2 cardiac complication risk•Chronic illnesses associated with increased SARS-CoV-2 cardiac complication risk•These associations were mostly conserved over differing geographical regions•Multidisciplinary approaches to chronic disease patient management are essential Virology; Omics
AbstractList Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management. • Older age and male sex associated with increased SARS-CoV-2 cardiac complication risk • Chronic illnesses associated with increased SARS-CoV-2 cardiac complication risk • These associations were mostly conserved over differing geographical regions • Multidisciplinary approaches to chronic disease patient management are essential Virology; Omics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management. [Display omitted] •Older age and male sex associated with increased SARS-CoV-2 cardiac complication risk•Chronic illnesses associated with increased SARS-CoV-2 cardiac complication risk•These associations were mostly conserved over differing geographical regions•Multidisciplinary approaches to chronic disease patient management are essential Virology; Omics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.
ArticleNumber 102264
Author Wan, Ke-Qiang
Cao, Chun-Feng
Wang, Hai-Qiang
Ma, Kun-Long
Zhu, Yanshan
Redd, Meredith A.
Kong, Ling-Xi
Ma, Wei
Shi, Haiyan
Gallo, Linda A.
Liao, Juan
Arentz, Matt
Sinclair, Jane E.
Short, Kirsty R.
Xu, Gang
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CitedBy_id crossref_primary_10_1016_j_foodres_2021_110798
crossref_primary_10_1016_j_hrtlng_2022_01_001
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Snippet Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to...
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Title A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection
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