A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

• Published in: iScience Vol. 24; no. 4; p. 102264
• Main Authors: Sinclair, Jane E., Zhu, Yanshan, Xu, Gang, Ma, Wei, Shi, Haiyan, Ma, Kun-Long, Cao, Chun-Feng, Kong, Ling-Xi, Wan, Ke-Qiang, Liao, Juan, Wang, Hai-Qiang, Arentz, Matt, Redd, Meredith A., Gallo, Linda A., Short, Kirsty R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.04.2021; Elsevier
• Subjects: Omics; Virology; Omics; Virology
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2021.102264

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management. [Display omitted] •Older age and male sex associated with increased SARS-CoV-2 cardiac complication risk•Chronic illnesses associated with increased SARS-CoV-2 cardiac complication risk•These associations were mostly conserved over differing geographical regions•Multidisciplinary approaches to chronic disease patient management are essential Virology; Omics