Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active

Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLH...

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Bibliographic Details
Published inReproductive biomedicine online Vol. 32; no. 6; pp. 635 - 641
Main Authors Kanamarlapudi, Venkateswarlu, Gordon, Uma D, López Bernal, Andrés
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.06.2016
Subjects
ADP-Ribosylation Factor 6
ADP-Ribosylation Factors - metabolism
ARF6
cAMP
Chorionic Gonadotropin - metabolism
Cyclic AMP - metabolism
Female
Follicular Fluid - metabolism
Granulosa Cells - cytology
GTP Phosphohydrolases - chemistry
human granulosa cells
Humans
LHCGR
Lutein - chemistry
Luteinizing Hormone - metabolism
Obstetrics and Gynecology
Ovarian Follicle - metabolism
Ovary - metabolism
Ovulation - metabolism
PCOS
Polycystic Ovary Syndrome - metabolism
Receptors, LH - metabolism
Time Factors
LHCGR
PCOS
cAMP
human granulosa cells
ARF6
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Summary:Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLHCGR internalisation is unaltered in PCOS GCs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2016.03.003