Non-coding RNAs and glioblastoma: Insight into their roles in metastasis

• Published in: Molecular therapy. Oncolytics Vol. 24; pp. 262 - 287
• Main Authors: Mousavi, Seyed Mojtaba, Derakhshan, Maryam, Baharloii, Fatereh, Dashti, Fatemeh, Mirazimi, Seyed Mohammad Ali, Mahjoubin-Tehran, Maryam, Hosseindoost, Saereh, Goleij, Pouya, Rahimian, Neda, Hamblin, Michael R., Mirzaei, Hamed
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.03.2022; American Society of Gene & Cell Therapy; Elsevier
• Subjects: circular RNA; glioblastoma; long non-coding RNA; metastasis; microRNA; non-coding RNA; Review; microRNA; long non-coding RNA; glioblastoma; non-coding RNA; metastasis; circular RNA
• ISSN: 2372-7705; 2372-7705
• DOI: 10.1016/j.omto.2021.12.015

Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate among all primary brain malignancies. Metastasis occurs as the tumor cells spread from the site of origin to another site in the brain. Metastasis is a multifactorial process, which depends on alterations in metabolism, genetic mutations, and the cancer microenvironment. During recent years, the scientific study of non-coding RNAs (ncRNAs) has led to new insight into the molecular mechanisms involved in glioma. Many studies have reported that ncRNAs play major roles in many biological procedures connected with the development and progression of glioma. Long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are all types of ncRNAs, which are commonly dysregulated in GBM. Dysregulation of ncRNAs can facilitate the invasion and metastasis of glioma. The present review highlights some ncRNAs that have been associated with metastasis in GBM. miRNAs, circRNAs, and lncRNAs are discussed in detail with respect to their relevant signaling pathways involved in metastasis. [Display omitted] These recent advances will shed more light on a thorough understanding of ncRNA function and the possible underlying molecular mechanisms involved in the regulation of metastasis. Their successful translation will depend on further interdisciplinary collaboration to improve tolerance, specificity, and delivery.