Exercise Mimetics: Impact on Health and Performance

The global epidemic of obesity and its associated chronic diseases is largely attributed to an imbalance between caloric intake and energy expenditure. While physical exercise remains the best solution, the development of muscle-targeted “exercise mimetics” may soon provide a pharmaceutical alternat...

Full description

Saved in:
Bibliographic Details
Published inCell metabolism Vol. 25; no. 2; pp. 242 - 247
Main Authors Fan, Weiwei, Evans, Ronald M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 07.02.2017
Subjects
Adenylate Kinase - metabolism
exercise
Exercise - physiology
exercise mimetics
Genome
Health
Humans
Muscle, Skeletal - physiology
Receptors, Cytoplasmic and Nuclear - metabolism
skeletal muscle
exercise mimetics
skeletal muscle
exercise
Online AccessGet full text

Cover

More Information
Summary:The global epidemic of obesity and its associated chronic diseases is largely attributed to an imbalance between caloric intake and energy expenditure. While physical exercise remains the best solution, the development of muscle-targeted “exercise mimetics” may soon provide a pharmaceutical alternative to battle an increasingly sedentary lifestyle. At the same time, these advances are fueling a raging debate on their escalating use as performance-enhancing drugs in high-profile competitions such as the Olympics. Exercise, especially endurance exercise, is known for its broad health benefits. In this Perspective, Fan et al. summarize exercise-induced transcriptional remodeling in skeletal muscle and present their perspectives of developing natural or synthetic “exercise mimetics” for therapeutic applications in patients that lack adequate physical exercise.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2016.10.022