Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research

Prior to the 21st century, genetic mechanisms that regulate sleep were largely unknown. In 1998, de Lecea et al. and Sakurai et al. reported the discovery of a gene they named hypocretin and orexin, respectively, which led to a revolution in our understanding of genetic and neuronal mechanisms that...

Full description

Saved in:
Bibliographic Details
Published inTrends in neurosciences (Regular ed.) Vol. 41; no. 2; pp. 70 - 72
Main Author Prober, David A.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2018
Subjects
Animals
arousal
Humans
hypocretin
Intracellular Signaling Peptides and Proteins - metabolism
Neurons - drug effects
Neuropeptides - metabolism
orexin
Orexins - pharmacology
sleep
Sleep - drug effects
Sleep - physiology
Wakefulness - drug effects
Wakefulness - physiology
sleep
hypocretin
orexin
arousal
Online AccessGet full text

Cover

More Information
Summary:Prior to the 21st century, genetic mechanisms that regulate sleep were largely unknown. In 1998, de Lecea et al. and Sakurai et al. reported the discovery of a gene they named hypocretin and orexin, respectively, which led to a revolution in our understanding of genetic and neuronal mechanisms that regulate sleep.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2017.11.007