Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients
Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyz...
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Published in | Journal of microbiology, immunology and infection Vol. 55; no. 3; pp. 421 - 427 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier B.V
01.06.2022
Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19.
We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one of the largest HLA-typed patient cohort to date.
Our results show that there is no relationship between HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19.
Our results may contribute to resolve the contradictory data on the role of HLA polymorphisms in COVID-19 infection. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to the work. |
ISSN: | 1684-1182 1995-9133 1995-9133 |
DOI: | 10.1016/j.jmii.2021.08.009 |