TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma

• Published in: Journal of pathology and translational medicine Vol. 56; no. 1; pp. 53 - 56
• Main Authors: Mehta, Anurag, Diwan, Himanshi, Bansal, Divya, Gupta, Manoj
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Pathologists, Korean Society for Cytopathology 01.01.2022; The Korean Society of Pathologists/The Korean Society for Cytopathology; Korean Society of Pathologists & the Korean Society for Cytopathology; 대한병리학회
• Subjects: Biopsy; brg1; Case Study; Kinases; Laboratories; lung; Lung cancer; Morphology; Mutation; non-small cell lung carcinoma; Ovaries; Protein expression; Proteins; Sarcoma; smarca4; Thyroid gland; thyroid transcription factor 1; Tomography; Transcription factors; Tumors; 병리학; BRG1; Thyroid transcription factor 1; Lung; Non–small cell lung carcinoma; SMARCA4
• ISSN: 2383-7837; 2383-7845
• DOI: 10.4132/jptm.2021.09.16

SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non-small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.