Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts

Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications i...

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Published inRevista brasileira de farmacognosia Vol. 25; no. 6; pp. 657 - 662
Main Authors Machado, Levi P., Carvalho, Luciana R., Young, Maria Cláudia M., Cardoso-Lopes, Elaine M., Centeno, Danilo C., Zambotti-Villela, Leonardo, Colepicolo, Pio, Yokoya, Nair S.
Format Journal Article
LanguageEnglish
Published Cham Elsevier Editora Ltda 01.11.2015
Springer International Publishing
Sociedade Brasileira de Farmacognosia
Subjects
acetylcholinesterase
Acetylcholinesterase inhibition
Alzheimer disease
bioactive compounds
biodiversity
Brazil
gas chromatography-mass spectrometry
Halogenated monoterpenes
Hypnea
macroalgae
monoterpenoids
Ochtodes
Original Article
people
PHARMACOLOGY & PHARMACY
Pharmacy
phytotherapy
Pterocladiella
Rhodophyta
Brazil
Acetylcholinesterase inhibition
Rhodophyta
Hypnea
Pterocladiella
Halogenated monoterpenes
Ochtodes
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Summary:Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400μg/ml. The chemical composition of the bioactive fraction was determined by gas chromatography–mass spectrometry (GC–MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them.
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ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2015.09.003