Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 16; p. 8530
Main Authors Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 08.08.2021
MDPI
Subjects
Angiogenesis
Bone marrow
Cancer
CCL2-CCR2 axis
CCR2 protein
Cell division
Cell proliferation
Chemokines
Chemotactic factors
Cytokines
Cytotoxicity
Endothelium
Esophagus
Inflammatory diseases
Invasiveness
Kinases
Leukocytes
Lymphocytes
Medical prognosis
Metastasis
Monocyte chemoattractant protein 1
Proteins
Review
Roles
Tumor microenvironment
Tumor necrosis factor-TNF
Tumors
Vascular endothelial growth factor
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Summary:Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22168530