Recurrent Cushing's Disease Associated with Nephrotic Syndrome

• Published in: Internal Medicine Vol. 34; no. 1; pp. 10 - 14
• Main Authors: TATSUMI, Tomohide, MORISHIMA, Toyohiko, WATARAI, Takao, KUBOTA, Masashi, KODAMA, Mineo, MATSUHISA, Munehide, IMANO, Eiichi, IZUMI, Masaaki, TAKAMA, Toshiro, SHIN, SungHyo, KAWANO, Kiyoshi, KAWAMORI, Ryuzo, KAMADA, Takenobu
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1995; Japanese Society of Internal Medicine
• Subjects: Adult; Biological and medical sciences; Cushing Syndrome - complications; Cushing Syndrome - pathology; Cushing Syndrome - therapy; Endocrinopathies; gamma knife; Glomerulonephritis, Membranoproliferative - complications; Glomerulonephritis, Membranoproliferative - pathology; Humans; Hypothalamus. Hypophysis. Epiphysis (diseases); Kidney - ultrastructure; Male; Medical sciences; Nephrotic Syndrome - etiology; Nephrotic Syndrome - pathology; Nephrotic Syndrome - therapy; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Recurrence; steroid therapy; transcranial surgery; transsphenoidal adenomectomy; Endocrinopathy; Glomerulonephritis; Human; Postoperative; Recurrence; Nervous system diseases; Urinary system disease; Cushing syndrome; Renal disease; Nephrotic syndrome; Adenoma; Case study; Association; Pituitary diseases; Pituitary gland; Benign neoplasm
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.34.10

A case of recurrent Cushing's disease with nephrotic syndrome due to membranoproliferative glomerulonephritis (MPGN) is presented. Functional pituitary adenoma recurred 6 years after transsphenoidal pituitary adenomectomy. Due to infiltration into the surrounding tissues, transcranial surgery was performed. However, this failed to induce a remission and thus gamma knife therapy was applied. Histopathological evaluation revealed that the glomerular lesions had progressed to a rather advanced stage of MPGN. Although this association could be coincidental, the recurrence of pituitary macroadenoma might be induced by the cessation of steroid treatment for the nephrotic syndrome. (Internal Medicine 34: 10-14, 1995)