Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 9; p. 2379
• Main Authors: Limbadri, Salendra, Luo, Xiaowei, Lin, Xiuping, Liao, Shengrong, Wang, Junfeng, Zhou, Xuefeng, Yang, Bin, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.09.2018; MDPI
• Subjects: Absolute configuration; Acids; Alkaloids; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; antibacterial activity; Antifungal activity; Aquatic Organisms; Aspergillus fumigatus; Aspergillus fumigatus - chemistry; Aspergillus fumigatus SCSIO 41012; Bacteria - drug effects; Carbon; Cephalosporins; Circular dichroism; Data processing; Deep sea; deep sea-derived fungus; Density functional theory; Dichroism; Fungi; Fungi - drug effects; Fungicides; Fusarium oxysporum; indole alkaloids; Indole Alkaloids - chemistry; Indole Alkaloids - isolation & purification; Indole Alkaloids - pharmacology; Indoles; Laboratories; Magnetic Resonance Spectroscopy; Malt; Marine ecology; Mass spectrometry; Mass spectroscopy; Metabolites; Microbial Sensitivity Tests; Minimum inhibitory concentration; Molecular Structure; Natural products; NMR; Nuclear magnetic resonance; Spectrum analysis; Steroid hormones; Steroids; Steroids - chemistry; Steroids - isolation & purification; Steroids - pharmacology; Sterols; Two dimensional analysis; China; antibacterial activity; indole alkaloids; steroids; Aspergillus fumigatus SCSIO 41012; deep sea-derived fungus; antifungal activity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23092379

Two new alkaloids, fumigatosides E ( ) and F ( ), and a new natural product, 3, 7-diketo-cephalosporin P₁ ( ) along with five known compounds ( ⁻ , , ) were isolated from deep-sea derived fungal SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound showed significant antifungal activity against f. sp. with MIC at 1.56 µg/mL. Compound exhibited significant higher activity against (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound exhibited significant activity against ATCC 19606 with a MIC value of 6.25 µg/mL.