Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 3; p. 371
• Main Authors: Payne, Ashley, Nahashon, Samuel, Taka, Equar, Adinew, Getinet M, Soliman, Karam F A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.02.2022; MDPI
• Subjects: Aging; aging and epigallocatechin-3-gallate (EGCG); Alzheimer Disease - metabolism; Alzheimer's disease; Alzheimer’s disease (AD); Amyloid beta-Peptides; Antioxidants; Catechin - analogs & derivatives; Epigallocatechin gallate; Etiology; Functional foods & nutraceuticals; Green tea; Humans; Inflammation; microglia; Mitochondria; Neurodegeneration; Neurodegenerative diseases; Neuroinflammatory Diseases; Neuroprotection; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Oxidative stress; Parkinson's disease; Pathology; Phytochemicals; Reactive oxygen species; Review; United States > US; aging and epigallocatechin-3-gallate (EGCG); Alzheimer’s disease (AD); inflammation; microglia; oxidative stress
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom12030371

Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer's disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression due to its antioxidant, anti-inflammatory, and anti-aging abilities. This report also re-examines the current literature and provides innovative approaches for EGCG to be used as a preventive measure to alleviate AD and other neurodegenerative disorders.