Impact of HIV-1, HIV-2, and HIV-1+2 dual infection on the outcome of tuberculosis

• Published in: International journal of infectious diseases Vol. 32; no. C; pp. 128 - 134
• Main Authors: Wejse, C, Patsche, C.B, Kühle, A, Bamba, F.J.V, Mendes, M.S, Lemvik, G, Gomes, V.F, Rudolf, F
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.03.2015; Elsevier
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Coinfection - epidemiology; Coinfection - mortality; Female; Follow-Up Studies; Guinea-Bissau - epidemiology; HIV Infections - complications; HIV Infections - epidemiology; HIV-1; HIV-2; Humans; Incidence; Infectious Disease; Longitudinal Studies; Male; Middle Aged; Mortality; Prevalence; Prospective Studies; Pulmonary/Respiratory; Treatment Outcome; Tuberculosis; Tuberculosis - diagnosis; Tuberculosis - drug therapy; Tuberculosis - epidemiology; Tuberculosis - mortality; Young Adult; Guinea-Bissau; HIV-1; Tuberculosis; HIV-2; Mortality
• ISSN: 1201-9712; 1878-3511
• DOI: 10.1016/j.ijid.2014.12.015

Highlights • In West Africa both HIV-1 and HIV-2 are prevalent and have different impacts on tuberculosis (TB) risk and outcome. • We included 1312 patients in this study, of whom 379 were HIV-infected: 241 had HIV-1, 93 had HIV-2, and 45 were HIV-1+2 dually infected. • The HIV type-associated risk of TB was 6-fold higher for HIV-1, 7-fold higher for HIV-1+2 dual infection, and 2-fold higher for HIV-2, compared with the HIV-uninfected. • More females than males were HIV-infected (36% vs. 25%; p < 0.001) and more females had a body mass index (BMI) <15 kg/m2 (11% vs. 6%; p < 0.001). • Of the patients included, 144 (11%) died: 62 (12%) among females and 82 (9%) among males. • HIV infection increased the mortality risk, with HIV-1 infection displaying the highest hazard ratio (HR) at 5, followed by HIV-1+2 infection (HR 4.2) and HIV-2 infection (HR 2.1).