Acute exacerbations of chronic obstructive pulmonary disease with low serum procalcitonin values do not benefit from antibiotic treatment: a prospective randomized controlled trial

Highlights • Mostpatients with acute exacerbations of COPDhave lowprocalcitonin (PCT) values. • Antibiotictherapywerenot better than placebo inpatients with PCT < 0.1 ng/ml. • Age≥75ys was predictive factor for requiring antibiotic therapy in patients with PCT<0.1 ng/ml.

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Bibliographic Details
Published inInternational journal of infectious diseases Vol. 48; no. C; pp. 40 - 45
Main Authors Wang, Jin-Xiang, Zhang, Shu-Ming, Xiao-HuiLi, Zhang, Yao, Xu, Zhen-Yang, Cao, Bin
Format Journal Article
LanguageEnglish
Published Canada Elsevier Ltd 01.07.2016
Elsevier
Subjects
Acute Disease - therapy
Acute exacerbation
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Calcitonin - blood
Calcitonin Gene-Related Peptide
Chronic obstructive pulmonary disease
Female
Hospitalization
Humans
Infectious Disease
Male
Middle Aged
Procalcitonin
Prospective Studies
Protein Precursors - blood
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary/Respiratory
Treatment Outcome
acute exacerbation
antibiotics
Procalcitonin
chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease
Antibiotics
Acute exacerbation
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Summary:Highlights • Mostpatients with acute exacerbations of COPDhave lowprocalcitonin (PCT) values. • Antibiotictherapywerenot better than placebo inpatients with PCT < 0.1 ng/ml. • Age≥75ys was predictive factor for requiring antibiotic therapy in patients with PCT<0.1 ng/ml.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2016.04.024