Developmental programming of the hypothalamus: a matter of fat

The influence of hormones on the development of brain circuits has long been recognized. A recent study shows that leptin has a similar effect on the emergence of feeding pathways. There might therefore be a crucial window during which a subject's basal metabolic phenotype can be altered.

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Bibliographic Details
Published inNature medicine Vol. 12; no. 1; pp. 52 - 53
Main Authors Horvath, Tamas L, Bruning, Jens C
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2006
Nature Publishing Group
Subjects
alpha-MSH - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Energy Metabolism
Genetic Predisposition to Disease
Hormones - metabolism
Humans
Hypothalamus - embryology
Hypothalamus - metabolism
Hypothalamus - physiology
Infectious Diseases
Leptin - metabolism
Metabolic Diseases
Mice
Models, Biological
Molecular Medicine
Neurons - metabolism
Neurosciences
news-and-views
Obesity - genetics
Obesity - metabolism
Phenotype
Signal Transduction
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Summary:The influence of hormones on the development of brain circuits has long been recognized. A recent study shows that leptin has a similar effect on the emergence of feeding pathways. There might therefore be a crucial window during which a subject's basal metabolic phenotype can be altered.
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ObjectType-News-1
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ISSN:1078-8956
1546-170X
DOI:10.1038/nm0106-52