Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cance...

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Bibliographic Details
Published inCell metabolism Vol. 20; no. 2; pp. 208 - 213
Main Authors Hardivillé, Stéphan, Hart, Gerald W.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 05.08.2014
Subjects
Acetylglucosamine - metabolism
AMP-Activated Protein Kinases - metabolism
Diabetes Mellitus - metabolism
Diabetes Mellitus - pathology
Epigenomics
Glycosylation
Humans
Neoplasms - metabolism
Neoplasms - pathology
Signal Transduction
Transcription, Genetic
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Summary:The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc’s regulation of cell physiology. The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Hardivillé and Hart review recent findings about O-GlcNAc’s regulation of cell physiology.
Bibliography:ObjectType-Article-2
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ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2014.07.014