Matrix-Assisted Laser Desorption and Electrospray Ionization Tandem Mass Spectrometry of Microbial and Synthetic Biodegradable Polymers

The in-depth structural and compositional investigation of biodegradable polymeric materials, neat or partly degraded, is crucial for their successful applications. Obviously, an exhaustive structural analysis of all synthetic macromolecules is essential in polymer chemistry to confirm the accomplis...

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Bibliographic Details
Published inPolymers Vol. 15; no. 10; p. 2356
Main Authors Rizzarelli, Paola, Rapisarda, Marco
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.05.2023
MDPI
Subjects
biodegradable polymers
characterization
Chemical reactions
Data processing
Degradation
Desorption
Electrospraying
ESI
Ionization
Ions
Macromolecules
MALDI
Mass spectrometry
Mechanical properties
Microorganisms
multi stage mass spectrometry
NMR
Nuclear magnetic resonance
Physical properties
Polymer chemistry
Polymer industry
Polymers
Review
Scientific imaging
Spectrum analysis
Structural analysis
tandem mass spectrometry
United Kingdom
drug delivery systems
multi stage mass spectrometry
tandem mass spectrometry
MALDI
biodegradable polymers
ESI
degradation
characterization
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Summary:The in-depth structural and compositional investigation of biodegradable polymeric materials, neat or partly degraded, is crucial for their successful applications. Obviously, an exhaustive structural analysis of all synthetic macromolecules is essential in polymer chemistry to confirm the accomplishment of a preparation procedure, identify degradation products originating from side reactions, and monitor chemical-physical properties. Advanced mass spectrometry (MS) techniques have been increasingly applied in biodegradable polymer studies with a relevant role in their further development, valuation, and extension of application fields. However, single-stage MS is not always sufficient to identify unambiguously the polymer structure. Thus, tandem mass spectrometry (MS/MS) has more recently been employed for detailed structure characterization and in degradation and drug release monitoring of polymeric samples, among which are biodegradable polymers. This review aims to run through the investigations carried out by the soft ionization technique matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and electrospray ionization mass spectrometry (ESI-MS) MS/MS in biodegradable polymers and present the resulting information.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym15102356