The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. We present experiment...

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Bibliographic Details
Published iniScience Vol. 22; pp. 28 - 43
Main Authors O'Melia, Meghan J., Lund, Amanda W., Thomas, Susan N.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.12.2019
Elsevier
Subjects
Biological Sciences Tools
Biomechanics
Biophysics
Lymphology
Review
Biomechanics
Lymphology
Biophysics
Biological Sciences Tools
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Summary:Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. We present experimental tools that enable quantitative analysis of lymphatic transport and lymph node dynamics in vitro and in vivo. Finally, we discuss the current understanding for how changes in lymphatic transport and lymph node biomechanics contribute to pathogenesis of conditions including cancer, aging, neurodegeneration, and infection. [Display omitted] Lymphology; Biophysics; Biomechanics; Biological Sciences Tools
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2019.11.005