Association Between Insulin-Like Growth Factor-1 and Frailty Among Older Adults

• Published in: The Journal of nutrition, health & aging Vol. 22; no. 1; pp. 68 - 72
• Main Authors: Doi, Takehiko, Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., Makino, K., Suzuki, T., Shimada, H.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.01.2018; Springer Paris; Springer Nature B.V
• Subjects: Activities of Daily Living; Aged; Aged, 80 and over; Aging; blood serum; Cognition; Cohort Studies; confidence interval; Cross-Sectional Studies; disability; elderly; Female; Frail Elderly; Frailty; Frailty - blood; Frailty - epidemiology; Geriatrics/Gerontology; Humans; IGF-1; Insulin; insulin-like growth factor I; Insulin-Like Growth Factor I - analysis; Insulin-like growth factors; logit analysis; Male; Medicine; Medicine & Public Health; Neurosciences; Nutrition; Odds Ratio; Older people; Primary Care Medicine; Quality of Life Research; frailty; disability; IGF-1
• ISSN: 1279-7707; 1760-4788; 1760-4788
• DOI: 10.1007/s12603-017-0916-1

Frailty is a course experienced in advanced aging. Identification of a biological factor associated with frailty is required. Although serum insulin-like growth factor-1 (IGF-1) is a potential factor related with frailty, consensus has not been reached regarding this relationship. This study aimed to investigate the association between IGF-1 and frailty in older adults. Cross-sectional study. Cohort study that was part of the “National Center for Geriatrics and Gerontology–Study of Geriatric Syndromes. The study participants were 4133 older adults (mean age, 71.8 ± 5.4 years). We assessed serum IGF-1 levels and frailty status and collected demographic variables, including cognitive function, as covariates. Frailty and pre-frailty were present in 274 subjects (7%) and 1930 subjects (47%), respectively. Subjects were divided into four groups based on quartiles of IGF-1 levels. Multinomial logistic analysis showed that the lowest group had significant odds of pre-frailty (crude model: odds ratio [OR] 1.58, 95% confidence interval [CI] 1.30–1.90, p <.001; adjusted model: OR 1.38, 95% CI 1.13–1.68, p =.002) and frailty (crude model: OR 3.42, 95% CI 2.38-4.92, p <.001; adjusted model: OR 1.54, 95% CI 1.02–2.32, p =.039), compared with the highest group. Lower serum IGF-1 levels were independently related with frailty in older adults.