Risk Factors Associated with Severe/Critical COVID-19 in People Living with HIV-1

• Published in: International journal of infectious diseases Vol. 122; pp. 152 - 154
• Main Authors: Bachelard, Antoine, Sautereau, Aurelie, Digumber, Marc, Isernia, Valentina, Phung, Bao, Lehur, Anne-Claire, Gac, Sylvie Le, Landman, Roland, Yazdanpanah, Yazdan, Ghosn, Jade
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.09.2022; The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases; Elsevier
• Subjects: COVID-19; COVID-19 - complications; COVID-19 Testing; Female; HIV; HIV Seropositivity; HIV-1; Humans; Middle Aged; Retrospective Studies; Risk Factors; SARS-CoV-2; COVID-19; HIV; Risk factors
• ISSN: 1201-9712; 1878-3511
• DOI: 10.1016/j.ijid.2022.05.055

•People living with HIV-1 are at greater risk of developing a severe form of COVID-19.•From February 2020 to November 2020, 129 people living with HIV-1 were infected with COVID-19 in our center.•The severity of COVID-19 was associated with older age, higher body mass index, and comorbidities.•Transgender women with HIV-1 were at higher risk for severe COVID-19. Our objective was to determine the risk factors of a “severe/critical” form of COVID-19 in a cohort of people living with HIV-1 (PLWH1) followed in the Bichat University Hospital center in PARIS, FRANCE. This study was an observational retrospective monocentric cohort of PLWH1 diagnosed with COVID-19 between February 1 st and November 31 st, 2020. Risk factors associated with “severe/critical” forms were determined using stepwise forward selection. One-hundred-and-twenty-nine PLWH1 with COVID-19 were included. COVID-19 diagnosis was confirmed in 98 cases (75.9%) and deemed probable according to the association of clinical criteria and contact case in 31 cases (24.1%). Clinical presentation of COVID-19 was “asymptomatic/mild/moderate” in 95 (73.6%), “severe” in 26 (21.7%) and “critical” in eight (6%). Patients with “severe/critical” COVID-19 tended to be older (median 54 year old), have a higher BMI (median 28.8 kg/m²) and were likely to have diabetes (9 versus 5) or chronic kidney disease (5 versus 2). Transgender women had higher risk too (OR: 4.9 (IC95: 1.35-24.0)). No association was observed between severity of COVID-19 and viral suppression or CD4 rates. Risk factors for severe COVID-19 were similar in PLWH1 than in the general population and PLWH1 transgender women were at higher risk.