Intragenic L1 Insertion: One Possibility of Brain Disorder

Long interspersed nuclear element 1 (LINE1, L1) is a retrotransposon comprising ~17% of the human genome. A subset of L1s maintains the potential to mobilize and alter the genomic landscape, consequently contributing to the change in genome integrity and gene expression. L1 retrotransposition occurs...

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Bibliographic Details
Published inLife (Basel, Switzerland) Vol. 12; no. 9; p. 1425
Main Authors Son, Ji-Hoon, Do, Hyunsu, Han, Jinju
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 13.09.2022
MDPI
Subjects
Algorithms
Brain
brain disorder
Copy number
Disorders
Expected values
Gene expression
Gene loci
Genes
Genomes
Genomics
Insertion
LINE1 (L1)
Proteins
Retrotransposition
retrotransposon
Review
RNA polymerase
Transposition
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Summary:Long interspersed nuclear element 1 (LINE1, L1) is a retrotransposon comprising ~17% of the human genome. A subset of L1s maintains the potential to mobilize and alter the genomic landscape, consequently contributing to the change in genome integrity and gene expression. L1 retrotransposition occurs in the human brain regardless of disease status. However, in the brain of patients with various brain diseases, the expression level and copy number of L1 are significantly increased. In this review, we briefly introduce the methodologies applied to measure L1 mobility and identify genomic loci where new insertion of L1 occurs in the brain. Then, we present a list of genes disrupted by L1 transposition in the genome of patients with brain disorders. Finally, we discuss the association between genes disrupted by L1 and relative brain disorders.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2075-1729
2075-1729
DOI:10.3390/life12091425