Etoricoxib prevents progression of osteolysis in repeated intra-articular monosodium urate-induced gouty arthritis in rats

• Published in: Journal of advanced research Vol. 24; pp. 109 - 120
• Main Authors: Lin, Yen-You, Jean, Yen-Hsuan, Lin, Sung-Chun, Feng, Chien-Wei, Kuo, Hsiao-Mei, Lai, Yu-Cheng, Kuo, Tsu-Jen, Chen, Nan-Fu, Lee, Hsin-Pai, Wen, Zhi-Hong
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier B.V 01.07.2020; Elsevier
• Subjects: Chronic, recurrent gouty arthritis; Micro-CT; Osteoclastogenesis; Rat model; Osteoclastogenesis; Micro-CT; Rat model; Chronic, recurrent gouty arthritis
• ISSN: 2090-1232; 2090-1224
• DOI: 10.1016/j.jare.2020.02.014

[Display omitted] •The chronic and repeated gouty arthritis (GA) could be induced by repeated-injection of monosodium urate (MSU) in the joints of rats.•The repeated attacks of MSU-induced chronic GA significantly produced osteoclast activated protein expression, osteolysis and cartilage degeneration.•NSAID, etoricoxib not only attenuated nociception but also played a protective role on cartilage in chronic and repeated attacks of GA.•NSAID, etoricoxib could attenuate the chronic and repeated gouty-induced osteoclastogenesis. Deposition of monosodium urate (MSU) crystals in the joint or synovium is the major factor in Gouty arthritis (GA). The clinical features of chronic and recurrent GA include pain and the subsequent development of chronic tophaceous GA with multiple tophi deposits accompanied by osteolysis. The majority of previous animal studies have focused on MSU-induced acute GA without making observations regarding osteolysis. In the study, intra-articular injections of MSU into the knee (2 times/week for 10 weeks) was used to induce chronic and recurrent attacks of GA that in turn induced progressive osteolysis. Moreover, we also evaluated whether the clinical, nonsteroidal anti-inflammatory drug (NSAID) etoricoxib attenuated the osteoclastogenesis of progressive osteolysis. The knee morphometry and the expression of osteoclastogenesis-related proteins (cathepsin K and matrix metalloproteinase-9 and -13) in the knee were examined by micro-CT and immunohistochemistry, respectively. Results showed that oral etoricoxib not only significantly attenuated the nociceptive behaviors of the rats but that it also inhibited the expression of osteoclastogenesis-related proteins in their knee joints in chronic and recurrent attacks of GA. Our findings thus suggest that NSAIDs not only inhibit nociception but also prevent the progression of osteolysis in chronic and repeated attacks of GA.