Increased 5-Bromo-2’-Deoxyuridine Incorporation in Various Brain Structures Following Passive Avoidance Training in Mice

We studied the effects of training on DNA synthesis intensity in mouse brain. Brain cells where DNA synthesis-associated processes took place under the influence of training were detected by immunohistochemical labeling of DNA molecules with synthetic thymine analogue 5-bromo-2’-deoxyuridine. The nu...

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Published inBulletin of experimental biology and medicine Vol. 153; no. 5; pp. 591 - 593
Main Authors Ivashkina, O. I., Zots, M. A., Bezriadnov, D. V., Anokhin, K. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.09.2012
Springer
Springer Nature B.V
Subjects
Analysis of Variance
Animals
Autoradiography
Avoidance Learning - physiology
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Bromodeoxyuridine - administration & dosage
Bromodeoxyuridine - metabolism
Bromodeoxyuridine - pharmacokinetics
Cell Biology
DNA
DNA - biosynthesis
DNA - metabolism
DNA synthesis
Immunohistochemistry
Injections, Intraperitoneal
Internal Medicine
Laboratory Medicine
Mice
Mice, Inbred C57BL
Pathology
Physiology
Statistics, Nonparametric
DNA synthesis
dentate gyrus
5-bromo-2’-deoxyuridine
long-term memory
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Summary:We studied the effects of training on DNA synthesis intensity in mouse brain. Brain cells where DNA synthesis-associated processes took place under the influence of training were detected by immunohistochemical labeling of DNA molecules with synthetic thymine analogue 5-bromo-2’-deoxyuridine. The number of 5-bromo-2’-deoxyuridine-positive cell increased in various structures of the brain under the influence of training.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1773-x