CNVDetector: locating copy number variations using array CGH data

• Published in: Bioinformatics Vol. 24; no. 23; pp. 2773 - 2775
• Main Authors: Chen, Peng-An, Liu, Hsiao-Fei, Chao, Kun-Mao
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.12.2008; Oxford Publishing Limited (England)
• Subjects: Algorithms; Biological and medical sciences; Comparative Genomic Hybridization - methods; Fundamental and applied biological sciences. Psychology; Gene Dosage; General aspects; Genetic Variation; Genome, Human; Humans; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Oligonucleotide Array Sequence Analysis; Variations; Copy number; Bioinformatics
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btn517

CNVDetector is a program for locating copy number variations (CNVs) in a single genome. CNVDetector has several merits: (i) it can deal with the array comparative genomic hybridization data even if the noise is not normally distributed; (ii) it has a linear time kernel; (iii) its parameters can be easily selected; (iv) it evaluates the statistical significance for each CNV calling. Availability: CNVDetector (for Windows platform) can be downloaded from http:www.csie.ntu.edu.tw/~kmchao/tools/CNVDetector/. The manual of CNVDetector is also available. Contact: kmchao@csie.ntu.edu.tw Supplementary information: Supplementary data are available at Bioinformatics online.