Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers

Cancer, as the second leading cause of death worldwide, is a major public health concern that imposes a heavy social and economic burden. Effective approaches for either diagnosis or therapy of most cancers are still lacking. Dynamic monitoring and personalized therapy are the main directions for ca...

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Published inLife (Basel, Switzerland) Vol. 11; no. 10; p. 1044
Main Authors Wang, Yi, Zhao, Ruichen, Jiao, Xueqiao, Wu, Longyuan, Wei, Yuxuan, Shi, Fuxiu, Zhong, Junpei, Xiong, Lixia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 04.10.2021
MDPI
Subjects
Angiogenesis
Biomarkers
Biomolecules
Biosynthesis
Cancer
Carcinogenesis
Carcinogens
Cell growth
clinical applications
Cytokines
Drug resistance
Extracellular vesicles
Gene expression
Growth factors
Kinases
Lipids
liquid biopsy
Lymphocytes
Medical prognosis
Metastasis
Nucleic acids
Proteins
Public health
Review
Roles
sEVs
T cell receptors
Vesicles
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Summary:Cancer, as the second leading cause of death worldwide, is a major public health concern that imposes a heavy social and economic burden. Effective approaches for either diagnosis or therapy of most cancers are still lacking. Dynamic monitoring and personalized therapy are the main directions for cancer research. Cancer-derived extracellular vesicles (EVs) are potential disease biomarkers. Cancer EVs, including small EVs (sEVs), contain unique biomolecules (protein, nucleic acid, and lipids) at various stages of carcinogenesis. In this review, we discuss the biogenesis of sEVs, and their functions in cancer, revealing the potential applications of sEVs as cancer biomarkers.
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These authors contributed equally to this work.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11101044