Molecular mechanisms of glioma invasiveness: the role of proteases

The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Cancer Vol. 3; no. 7; pp. 489 - 501
Main Author Rao, Jasti S
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.07.2003
Subjects
Cathepsin B - metabolism
Central Nervous System Neoplasms - metabolism
Central Nervous System Neoplasms - pathology
Central Nervous System Neoplasms - physiopathology
Control
Endopeptidases - physiology
Genetic aspects
Glioma - metabolism
Glioma - pathology
Glioma - physiopathology
Gliomas
Humans
Matrix Metalloproteinases - metabolism
Neoplasm Invasiveness
Neoplasm Recurrence, Local - metabolism
Physiological aspects
Plasminogen Activators - metabolism
Proteases
Receptors, Cell Surface - metabolism
Receptors, Urokinase Plasminogen Activator
Risk factors
Urokinase-Type Plasminogen Activator - metabolism
India
Online AccessGet full text

Cover

More Information
Summary:The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause of mortality and underscores the need to understand in more detail the mechanisms of tumour invasiveness. Several proteases influence the malignant characteristics of gliomas--could their inhibition prove to be a useful therapeutic strategy?
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:1474-175X
1474-1768
DOI:10.1038/nrc1121