Impact of split completeness on future liver remnant hypertrophy in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in hepatocellular carcinoma: Complete-ALPPS versus partial-ALPPS

• Published in: Surgery Vol. 161; no. 2; pp. 357 - 364
• Main Authors: Chan, Albert C.Y., MBBS, FCSHK, FHKAM, FRCS(Edin), Chok, Kenneth, MBBS, MS, FHKAM, FRCS(Edin), Dai, Jeff W.C., MBBS, FCSHK, FHKAM, FRCS(Edin), Lo, Chung Mau, MBBS, MS, FACS, FHKAM, FRCS(Edin), FRACS
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2017
• Subjects: Aged; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; Cohort Studies; Disease-Free Survival; Female; Hepatectomy - adverse effects; Hepatectomy - methods; Hepatic Veins - surgery; Hong Kong; Hospitals, University; Humans; Hypertrophy - pathology; Ligation; Liver - pathology; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - mortality; Liver Neoplasms - surgery; Male; Middle Aged; Neoplasm Invasiveness - pathology; Neoplasm Staging; Neoplasm, Residual - pathology; Postoperative Complications - mortality; Postoperative Complications - physiopathology; Prognosis; Retrospective Studies; Risk Assessment; Statistics, Nonparametric; Surgery; Survival Analysis; Tomography, X-Ray Computed - methods; Treatment Outcome
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/j.surg.2016.07.029

Background Recent evidence suggested that associating liver partition and portal vein ligation for staged hepatectomy with a partial split could effectively induce the same degree of future liver remnant hypertrophy as a complete split in non-cirrhotic and non-cholestatic livers with better postoperative safety profiles. Our aim was to evaluate if the same phenomenon could be applied to hepatitis-related chronic liver diseases. Methods In the study, 25 patients who underwent associating liver partition and portal vein ligation for staged hepatectomy from October 2013 to January 2016 for hepatocellular carcinoma were analyzed. Partial-associating liver partition and portal vein ligation for staged hepatectomy ( n  = 12) was defined as 50–80% of the transection surface split and complete-associating liver partition and portal vein ligation for staged hepatectomy ( n  = 13) was split down to inferior vena cava. Perioperative outcomes stratified by split completeness were evaluated. Results There was no significant difference in operating times and blood loss for stage I and II operations between complete-associating liver partition and portal vein ligation for staged hepatectomy and partial-associating liver partition and portal vein ligation for staged hepatectomy. All patients underwent stage II operation without any inter-stage complications. Complete split induced greater future liver remnant hypertrophy than partial split (hypertrophy rate: 31.2 vs 17.5 mL/day, P  = .022) with more pronounced effect in chronic hepatitis ( P  = .007) than cirrhosis ( P  = .283). Complete-associating liver partition and portal vein ligation for staged hepatectomy was more likely to attain a future liver remnant/estimated standard liver volume ratio >35% within 10 days (76.9% vs 33.3%, P  = .024) and proceed to stage II within 14 days after stage I (100% vs 58.4%, P  = .009). The overall postoperative morbidity (≥grade 3a) after stage II was 16% (complete versus partial split: 7.7% vs 25%, P  = .238) and hospital mortality after stage II was 8% (complete versus partial split: 0% vs 16.7%, P  = .125). Conclusion Complete-associating liver partition and portal vein ligation for staged hepatectomy induced more rapid future liver remnant hypertrophy than partial-associating liver partition and portal vein ligation for staged hepatectomy without increased perioperative risk in chronic liver diseases.